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Dr. Mallikarjun Kalashetty

Head, Hemato-Oncology, Bone Marrow Transplantation & Cellular Therapy
Manipal Hospitals, Old Airport Road, Bengaluru

About the guest:

Dr. Mallikarjun Kalashetty is a senior clinician and leader in hematological malignancies, stem cell transplantation, and cellular therapy, with extensive experience translating advanced therapies from global research into real-world clinical practice in India.

He is trained in Internal Medicine, followed by subspecialty training in Clinical Hematology and Hemato-Oncology, and has built his career at the intersection of complex patient care and evolving immunotherapeutic innovation. His clinical expertise spans both benign and malignant hematological disorders, with a particular focus on bone marrow transplantation and CAR-T cell therapy.

Dr. Kalashetty completed his MD in General Medicine at JN Medical College, followed by a DM in Clinical Hematology and Hemato-Oncology from KEM Hospital and Seth GS Medical College, one of India’s premier tertiary academic centers. He subsequently served as faculty before undertaking an advanced Bone Marrow Transplantation Fellowship in Vancouver, Canada, gaining exposure to international standards of transplant and cellular therapy care.

Clinical Focus
& Contributions

Dr. Kalashetty’s work centers on:
  • Treatment of hematological cancers including multiple myeloma, lymphomas, and acute leukemias
  • Autologous and allogeneic stem cell transplantation
  • Clinical application of CAR-T cell therapy and emerging cellular immunotherapies
  • Management of high-risk, relapsed-refractory disease where conventional therapies have failed

He has been closely involved in implementing CAR-T therapy in India, navigating not only the clinical complexities, such as cytokine release syndrome, neurotoxicity, and prolonged immune suppression but also the broader challenges of access, affordability, infrastructure, and patient selection in a resource-diverse healthcare system.

Perspective
& Leadership

Known for his grounded, patient-first approach, Dr. Kalashetty brings a pragmatic clinical lens to rapidly evolving therapies. He actively contributes to shaping how advanced treatments like CAR-T are delivered safely, ethically, and sustainably in the Indian context, bridging global evidence with local realities.

His work emphasizes that innovation in oncology must go hand-in-hand with training, systems readiness, multidisciplinary care, and long-term follow-up, especially as cellular therapies move beyond academic trials into routine practice.

Through platforms such as The Cure Circle, Dr. Kalashetty engages with clinicians, industry leaders, and innovators to discuss not just therapeutic breakthroughs, but the ecosystem changes required to make them meaningful for patients.

Episodes:

Episode 3

An in-depth conversation exploring next-generation T-cell therapies, including stem-like memory T cells, and what they...